mMaC myomesin B4

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SKU: mMaC myomesin B4

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DSHB Data Sheet

Catalog Fields

Clone ID/Product Name: mMaC myomesin B4
Available to For-Profits: Yes
Alternate Antibody Name:
Gene Symbol: MYOM1
Ab Isotype: MIgG1
Gene Name:
Antibody Registry ID: AB_760349 
Uniprot ID: Q90724 
RRID:  
Entrez Gene ID: 395805 
Clonality: Monoclonal
Immunogen: M-band protein fraction from pectoralis
Clone:
Immunogen Sequence: Full length sequence
Myeloma Strain: P3-NS1/lAg4-1
Epitope Mapped: No
Antigen Name: myomesin
Epitope Location or Sequence:
Alternate Antigen Name:
Deposit Date: 8/15/2006
Antigen Molecular Weight: 182.2 kDa
Depositor: Perriard, J.-C.
Antigen Sequence:
Depositor Institution: ETH-Honggerberg / Institute of Cell Biology
Antigen Species: chicken
Depositor Notes:
Host Species: mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Chicken, Fish, Mouse, Rabbit, Vertebrates, Xenopus, Zebrafish
Additional Information:
Predicted Species Reactivity:  
Human Protein Atlas:  
Additional Characterization:  
Recommended Applications: Immunofluorescence, Immunohistochemistry, Western Blot
All cell products contain the antimicrobial ProClin. Click here for additional information.
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
mMaC myomesin B4 was deposited to the DSHB by Perriard, J.-C. (DSHB Hybridoma Product mMaC myomesin B4)
Storage and Handling Recommendations
Although many cell products are maintained at 4°C for years without loss of activity, shelf-life at 4°C is highly variable. For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing.
Usage Recommendations
The optimal Ig concentration for an application varies by species and antibody affinity. For each product, the antibody titer must be optimized for every application by the end user laboratory. A good starting concentration for immunohistochemistry (IHC), immunofluorescence (IF), and immunocytochemistry (ICC) when using mouse Ig is 2-5 ug/ml. For western blots, the recommended concentration range of mouse Ig 0.2-0.5 ug/ml. In general, rabbit antibodies demonstrate greater affinity and are used at a magnitude lower Ig concentration for initial testing. The recommended concentrations for rabbit Ig are 0.2-0.5 ug/ml (IF, IHC and ICC) and 20-50 ng/ml (WB).

20 References

  • Initial Publication
  • IF References
  • WB References
  • IHC References
  • ELISA References
  • FFPE References
  • All References
  • Initial Publication

    A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies.
    Eppenberger HM
    The Journal of cell biology 98.2 (1984 Feb): 518-24.

    IF References

    Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.
    Zhong Y
    Proceedings of the National Academy of Sciences of the United States of America 105.2 (2008 Jan 15): 554-9.

    CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.
    Ladd AN
    Developmental dynamics : an official publication of the American Association of Anatomists 245.8 (2016 Aug): 854-73.

    CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.
    Ladd AN
    Developmental dynamics : an official publication of the American Association of Anatomists 245.8 (2016 Aug): 854-73.

    Proteomic analysis of laser capture microscopy purified myotendinous junction regions from muscle sections.
    Blanco G
    Proteome science 12. (2014): 25.

    RYBP is important for cardiac progenitor cell development and sarcomere formation.
    Pirity MK
    PloS one 15.7 (2020): e0235922.

    A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies.
    Eppenberger HM
    The Journal of cell biology 98.2 (1984 Feb): 518-24.

    Structure before function: myosin binding protein-C slow is a structural protein with regulatory properties.
    Kontrogianni-Konstantopoulos A
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32.12 (2018 Jun 6): fj201800624R.

    Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
    Kasahara H
    Scientific reports 9.1 (2019 Aug 29): 12580.

    Differences in titin segmental elongation between passive and active stretch in skeletal muscle.
    Herzog W
    The Journal of experimental biology 220.Pt 23 (2017 Dec 1): 4418-4425.

    Determination of the source of SHG verniers in zebrafish skeletal muscle.
    Pantazis P
    Scientific reports 5. (2015 Dec 11): 18119.

    Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
    Manganiello V
    The Journal of biological chemistry 290.11 (2015 Mar 13): 6763-76.

    Localization of sarcomeric proteins during myofibril assembly in cultured mouse primary skeletal myotubes.
    Sanger JM
    Anatomical record (Hoboken, N.J. : 2007) 297.9 (2014 Sep): 1571-84.

    Isolation and Culture of Neonatal Murine Primary Cardiomyocytes.
    Sundaresan NR
    Current protocols 1.7 (2021 Jul): e196.

    WB References

    CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.
    Ladd AN
    Developmental dynamics : an official publication of the American Association of Anatomists 245.8 (2016 Aug): 854-73.

    Structure before function: myosin binding protein-C slow is a structural protein with regulatory properties.
    Kontrogianni-Konstantopoulos A
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32.12 (2018 Jun 6): fj201800624R.

    Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
    Kasahara H
    Scientific reports 9.1 (2019 Aug 29): 12580.

    Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations.
    Kasahara H
    Frontiers in physiology 10. (2019): 696.

    Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.
    Bang ML
    Cardiovascular research 107.2 (2015 Jul 15): 216-25.

    IHC References

    Functional analysis of slow myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles.
    Du SJ
    Journal of genetics and genomics = Yi chuan xue bao 39.2 (2012 Feb): 69-80.

    Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers.
    Du SJ
    PloS one 6.12 (2011): e28524.

    Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos.
    Du SJ
    PloS one 5.1 (2010 Jan 1): e8416.

    Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.
    Zhong Y
    Proceedings of the National Academy of Sciences of the United States of America 105.2 (2008 Jan 15): 554-9.

    CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.
    Ladd AN
    Developmental dynamics : an official publication of the American Association of Anatomists 245.8 (2016 Aug): 854-73.

    CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.
    Ladd AN
    Developmental dynamics : an official publication of the American Association of Anatomists 245.8 (2016 Aug): 854-73.

    Structure before function: myosin binding protein-C slow is a structural protein with regulatory properties.
    Kontrogianni-Konstantopoulos A
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32.12 (2018 Jun 6): fj201800624R.

    Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death.
    Cooper KL
    eLife 8. (2019 Oct 15): .

    Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
    Kasahara H
    Scientific reports 9.1 (2019 Aug 29): 12580.

    Defective sarcomere assembly in smyd1a and smyd1b zebrafish mutants.
    Du S
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33.5 (2019 May): 6209-6225.

    Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
    Red-Horse K
    Nature communications 9.1 (2018 Jan 25): 368.

    Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
    Manganiello V
    The Journal of biological chemistry 290.11 (2015 Mar 13): 6763-76.

    ELISA References

    A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies.
    Eppenberger HM
    The Journal of cell biology 98.2 (1984 Feb): 518-24.

    FFPE References
    All References

    Functional analysis of slow myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles.
    Du SJ
    Journal of genetics and genomics = Yi chuan xue bao 39.2 (2012 Feb): 69-80.

    Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers.
    Du SJ
    PloS one 6.12 (2011): e28524.

    Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos.
    Du SJ
    PloS one 5.1 (2010 Jan 1): e8416.

    Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.
    Zhong Y
    Proceedings of the National Academy of Sciences of the United States of America 105.2 (2008 Jan 15): 554-9.

    CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart.
    Ladd AN
    Developmental dynamics : an official publication of the American Association of Anatomists 245.8 (2016 Aug): 854-73.

    Structure before function: myosin binding protein-C slow is a structural protein with regulatory properties.
    Kontrogianni-Konstantopoulos A
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32.12 (2018 Jun 6): fj201800624R.

    Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death.
    Cooper KL
    eLife 8. (2019 Oct 15): .

    Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
    Kasahara H
    Scientific reports 9.1 (2019 Aug 29): 12580.

    Defective sarcomere assembly in smyd1a and smyd1b zebrafish mutants.
    Du S
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33.5 (2019 May): 6209-6225.

    Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
    Red-Horse K
    Nature communications 9.1 (2018 Jan 25): 368.

    Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
    Manganiello V
    The Journal of biological chemistry 290.11 (2015 Mar 13): 6763-76.

    Proteomic analysis of laser capture microscopy purified myotendinous junction regions from muscle sections.
    Blanco G
    Proteome science 12. (2014): 25.

    RYBP is important for cardiac progenitor cell development and sarcomere formation.
    Pirity MK
    PloS one 15.7 (2020): e0235922.

    A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies.
    Eppenberger HM
    The Journal of cell biology 98.2 (1984 Feb): 518-24.

    Differences in titin segmental elongation between passive and active stretch in skeletal muscle.
    Herzog W
    The Journal of experimental biology 220.Pt 23 (2017 Dec 1): 4418-4425.

    Determination of the source of SHG verniers in zebrafish skeletal muscle.
    Pantazis P
    Scientific reports 5. (2015 Dec 11): 18119.

    Localization of sarcomeric proteins during myofibril assembly in cultured mouse primary skeletal myotubes.
    Sanger JM
    Anatomical record (Hoboken, N.J. : 2007) 297.9 (2014 Sep): 1571-84.

    Isolation and Culture of Neonatal Murine Primary Cardiomyocytes.
    Sundaresan NR
    Current protocols 1.7 (2021 Jul): e196.

    Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations.
    Kasahara H
    Frontiers in physiology 10. (2019): 696.

    Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.
    Bang ML
    Cardiovascular research 107.2 (2015 Jul 15): 216-25.

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