orb 4H8-s

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SKU: orb 4H8-s

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DSHB Data Sheet
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Catalog Fields

Clone ID/Product Name: orb 4H8-s
Available to For-Profits: Yes
Alternate Antibody Name:
Gene Symbol: orb
Ab Isotype: MIgG1, lambda light chain
Gene Name:
Antibody Registry ID: AB_528418 
Uniprot ID: Q9VCN7 
RRID:  
Entrez Gene ID: 42752 
Clonality: Monoclonal
Immunogen: Recombinant fusion protein of phage T7 gene Phi10 and Oo18 RNA-binding protein (aa 94-765 of 915 aa isoform [Uniprot ID Q9VCN7])
Clone:
Immunogen Sequence: Partial protein
Myeloma Strain: Sp2/0
Epitope Mapped: Yes
Antigen Name: orb protein
Epitope Location or Sequence: aa 94-765 of 915 aa isoform [Uniprot ID Q9VCN7], containing the rrm (RNA recognition motif) regions
Alternate Antigen Name:
Deposit Date: 3/16/1999
Antigen Molecular Weight: Multiple isoforms; major bands have an apparent MW between 97 and 100 kDa
Depositor: Schedl, P.
Antigen Sequence:
Depositor Institution: Princeton University
Antigen Species: Drosophila
Depositor Notes:
Host Species: mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Drosophila
Additional Information: orb is a RNA binding protein
Predicted Species Reactivity:  
Human Protein Atlas:  
Additional Characterization:  
Recommended Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
All cell products contain the antimicrobial ProClin. Click here for additional information.
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
orb 4H8-s was deposited to the DSHB by Schedl, P. (DSHB Hybridoma Product orb 4H8-s)
Storage and Handling Recommendations
Usage Recommendations

21 References

  • Initial Publication
  • IF References
  • WB References
  • IHC References
  • IP References
  • Epitope Map References
  • All References
    • Initial Publication

    The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.
    Schedl P
    Genes & development 8.5 (1994 Mar 1): 598-613.

    IF References

    The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.
    Schedl P
    PLoS genetics 8.11 (2012): e1003079.

    The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.
    Schedl P
    Genes & development 8.5 (1994 Mar 1): 598-613.

    A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity.
    St Johnston D
    Nature 421.6921 (2003 Jan 23): 379-84.

    Cup blocks the precocious activation of the orb autoregulatory loop.
    Schedl P
    PloS one 6.12 (2011): e28261.

    The Synaptonemal complex component C(2)M regulates meiotic crossing over in Drosophila.
    McKim KS
    Current biology : CB 13.4 (2003 Feb 18): 276-85.

    Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila.
    González-Reyes A
    PLoS biology 10.4 (2012): e1001298.

    Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
    Knoblich JA
    Nature 454.7201 (2008 Jul 10): 241-5.

    Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization.
    Tulin AV
    Nature communications 3. (2012 Mar 27): 760.

    H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila.
    Kobayashi S
    Biology open 4.2 (2015 Jan 8): 119-24.

    The master switch gene sex-lethal promotes female development by negatively regulating the N-signaling pathway.
    Schedl P
    Developmental cell 12.2 (2007 Feb): 275-86.

    Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.
    Lasko P
    Developmental cell 13.5 (2007 Nov): 691-704.

    Kinase-activity-independent functions of atypical protein kinase C in Drosophila.
    Wodarz A
    Journal of cell science 122.Pt 20 (2009 Oct 15): 3759-71.

    Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.
    Wodarz A
    PLoS genetics 5.9 (2009 Sep): e1000644.

    Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis.
    Lasko P
    PloS one 10.4 (2015): e0122519.

    Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation.
    Ratnaparkhi A
    Development (Cambridge, England) 146.13 (2019 Jul 10): .

    Gatekeeper function for Short stop at the ring canals of the Drosophila ovary.
    Gelfand VI
    Current biology : CB 31.15 (2021 Aug 9): 3207-3220.e4.

    Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control.
    Calvi BR
    eLife 11. (2022 Jan 13): .

    WB References

    The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.
    Schedl P
    PLoS genetics 8.11 (2012): e1003079.

    RNA helicase Spn-E is required to maintain Aub and AGO3 protein levels for piRNA silencing in the germline of Drosophila.
    Olenina LV
    European journal of cell biology 95.9 (2016 Sep): 311-22.

    The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.
    Schedl P
    Genes & development 8.5 (1994 Mar 1): 598-613.

    Cup blocks the precocious activation of the orb autoregulatory loop.
    Schedl P
    PloS one 6.12 (2011): e28261.

    Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
    Schedl P
    PloS one 8.9 (2013): e72864.

    IHC References

    Ovarian somatic Piwi regulates nurse cell proliferation and oocyte specification in Drosophila.
    Lin H
    microPublication biology 2020. (2020 Nov 18): .

    Piwi in the stem cell niche regulates nurse cell number and oocyte specification.
    Lin H
    microPublication biology 2020. (2020 Nov 18): .

    IP References

    Cup blocks the precocious activation of the orb autoregulatory loop.
    Schedl P
    PloS one 6.12 (2011): e28261.

    Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
    Schedl P
    PloS one 8.9 (2013): e72864.

    Epitope Map References

    The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.
    Schedl P
    Genes & development 8.5 (1994 Mar 1): 598-613.

    All References

    Ovarian somatic Piwi regulates nurse cell proliferation and oocyte specification in Drosophila.
    Lin H
    microPublication biology 2020. (2020 Nov 18): .

    Piwi in the stem cell niche regulates nurse cell number and oocyte specification.
    Lin H
    microPublication biology 2020. (2020 Nov 18): .

    The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.
    Schedl P
    PLoS genetics 8.11 (2012): e1003079.

    The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.
    Schedl P
    Genes & development 8.5 (1994 Mar 1): 598-613.

    A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity.
    St Johnston D
    Nature 421.6921 (2003 Jan 23): 379-84.

    Cup blocks the precocious activation of the orb autoregulatory loop.
    Schedl P
    PloS one 6.12 (2011): e28261.

    The Synaptonemal complex component C(2)M regulates meiotic crossing over in Drosophila.
    McKim KS
    Current biology : CB 13.4 (2003 Feb 18): 276-85.

    Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila.
    González-Reyes A
    PLoS biology 10.4 (2012): e1001298.

    Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
    Knoblich JA
    Nature 454.7201 (2008 Jul 10): 241-5.

    Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization.
    Tulin AV
    Nature communications 3. (2012 Mar 27): 760.

    H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila.
    Kobayashi S
    Biology open 4.2 (2015 Jan 8): 119-24.

    The master switch gene sex-lethal promotes female development by negatively regulating the N-signaling pathway.
    Schedl P
    Developmental cell 12.2 (2007 Feb): 275-86.

    Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.
    Lasko P
    Developmental cell 13.5 (2007 Nov): 691-704.

    Kinase-activity-independent functions of atypical protein kinase C in Drosophila.
    Wodarz A
    Journal of cell science 122.Pt 20 (2009 Oct 15): 3759-71.

    Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.
    Wodarz A
    PLoS genetics 5.9 (2009 Sep): e1000644.

    Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis.
    Lasko P
    PloS one 10.4 (2015): e0122519.

    Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation.
    Ratnaparkhi A
    Development (Cambridge, England) 146.13 (2019 Jul 10): .

    Gatekeeper function for Short stop at the ring canals of the Drosophila ovary.
    Gelfand VI
    Current biology : CB 31.15 (2021 Aug 9): 3207-3220.e4.

    Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control.
    Calvi BR
    eLife 11. (2022 Jan 13): .

    RNA helicase Spn-E is required to maintain Aub and AGO3 protein levels for piRNA silencing in the germline of Drosophila.
    Olenina LV
    European journal of cell biology 95.9 (2016 Sep): 311-22.

    Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
    Schedl P
    PloS one 8.9 (2013): e72864.

    Back

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